6OPI

phosphorylated ERK2 with SCH-CPD336

6OPI の概要

• エントリーDOI: 10.2210/pdb6opi/pdb
• 分子名称: Mitogen-activated protein kinase 1, (3R)-N-[3-(2-cyclopropylpyridin-4-yl)-1H-indazol-5-yl]-3-(methoxymethyl)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}ethyl)pyrrolidine-3-carboxamide (3 entities in total)
• 機能のキーワード: erk 2, mitogen activated protein kinase 2, map kinase 2, signaling protein, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41802.82

構造登録者

Vigers, G.P.,Smith, D. (登録日: 2019-04-25, 公開日: 2019-07-31, 最終更新日: 2023-11-15)

• 主引用文献: Pegram, L.M.,Liddle, J.C.,Xiao, Y.,Hoh, M.,Rudolph, J.,Iverson, D.B.,Vigers, G.P.,Smith, D.,Zhang, H.,Wang, W.,Moffat, J.G.,Ahn, N.G.; Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2.; Proc.Natl.Acad.Sci.USA, 116:15463-15468, 2019; PubMed: 31311868; DOI: 10.1073/pnas.1906824116

実験手法

X-RAY DIFFRACTION (3 Å)