6OP0

Asymmetric hTNF-alpha

6OP0 の概要

• エントリーDOI: 10.2210/pdb6op0/pdb
• 分子名称: Tumor necrosis factor, (R)-{1-[(2,5-dimethylphenyl)methyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl}(pyridin-4-yl)methanol (3 entities in total)
• 機能のキーワード: tumour necrosis factor alpha, tnf, asymmetric, protein-protein interaction inhibitor, rheumatoid arthritis, cytokine
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 52796.72

構造登録者

Arakaki, T.L.,Edwards, T.E.,Fairman, J.W.,Davies, D.R.,Foley, A.,Ceska, T. (登録日: 2019-04-23, 公開日: 2019-12-25, 最終更新日: 2024-04-03)

• 主引用文献: O'Connell, J.,Porter, J.,Kroeplien, B.,Norman, T.,Rapecki, S.,Davis, R.,McMillan, D.,Arakaki, T.,Burgin, A.,Fox Iii, D.,Ceska, T.,Lecomte, F.,Maloney, A.,Vugler, A.,Carrington, B.,Cossins, B.P.,Bourne, T.,Lawson, A.; Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.; Nat Commun, 10:5795-5795, 2019; PubMed: 31857588; DOI: 10.1038/s41467-019-13616-1

実験手法

X-RAY DIFFRACTION (2.55 Å)