6OOO

Crystal structure of HIV-1 LM/HT Clade A/E CRF01 gp120 core in complex with (S)-MCG-IV-226.

Summary for 6OOO

Entry DOI	10.2210/pdb6ooo/pdb
Descriptor	HIV-1 LM/HT Clade A/E CRF01 gp120, 2-acetamido-2-deoxy-beta-D-glucopyranose, (3S,5R)-5-amino-N~3~-(4-chloro-3-fluorophenyl)-N~1~-propylpiperidine-1,3-dicarboxamide, ... (5 entities in total)
Functional Keywords	hiv-1 gp120, clade a/e cf01, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	1
Total formula weight	42273.96
Authors	Tolbert, W.D.,Sherburn, R.,Pazgier, M. (deposition date: 2019-04-23, release date: 2020-03-11, Last modification date: 2023-10-11)
Primary citation	Grenier, M.C.,Ding, S.,Vezina, D.,Chapleau, J.P.,Tolbert, W.D.,Sherburn, R.,Schon, A.,Somisetti, S.,Abrams, C.F.,Pazgier, M.,Finzi, A.,Smith 3rd, A.B. Optimization of Small Molecules That Sensitize HIV-1 Infected Cells to Antibody-Dependent Cellular Cytotoxicity. Acs Med.Chem.Lett., 11:371-378, 2020 Cited by PubMed: 32184972 DOI: 10.1021/acsmedchemlett.9b00445 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation