6ONI

Crystal structure of PPARgamma ligand binding domain in complex with N-CoR peptide and inverse agonist T0070907

6ONI の概要

• エントリーDOI: 10.2210/pdb6oni/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, NCOR isoform c, 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, ... (4 entities in total)
• 機能のキーワード: nuclear receptors, tzds, drug design, therapeutic targets, transcription, transcription-agonist complex, transcription/agonist
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34236.01

構造登録者

Shang, J.,Kojetin, D.J. (登録日: 2019-04-22, 公開日: 2020-03-04, 最終更新日: 2023-10-11)

• 主引用文献: Shang, J.,Mosure, S.A.,Zheng, J.,Brust, R.,Bass, J.,Nichols, A.,Solt, L.A.,Griffin, P.R.,Kojetin, D.J.; A molecular switch regulating transcriptional repression and activation of PPAR gamma.; Nat Commun, 11:956-956, 2020; PubMed: 32075969; DOI: 10.1038/s41467-020-14750-x

実験手法

X-RAY DIFFRACTION (1.8 Å)