6OJS
Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP, MTX and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-D-glutamic acid
Summary for 6OJS
Entry DOI | 10.2210/pdb6ojs/pdb |
Descriptor | Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, ... (5 entities in total) |
Functional Keywords | inhibitor, ts, ts-dhfr, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Cryptosporidium hominis |
Total number of polymer chains | 5 |
Total formula weight | 311009.68 |
Authors | Czyzyk, D.J.,Anderson, K.S.,Jorgensen, W.L.,Valhondo, M. (deposition date: 2019-04-12, release date: 2019-06-19, Last modification date: 2023-10-11) |
Primary citation | Czyzyk, D.J.,Valhondo, M.,Jorgensen, W.L.,Anderson, K.S. Understanding the structural basis of species selective, stereospecific inhibition for Cryptosporidium and human thymidylate synthase. Febs Lett., 593:2069-2078, 2019 Cited by PubMed: 31172516DOI: 10.1002/1873-3468.13474 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.214 Å) |
Structure validation
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