6OJS

Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP, MTX and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-D-glutamic acid

6OJS の概要

• エントリーDOI: 10.2210/pdb6ojs/pdb
• 分子名称: Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: inhibitor, ts, ts-dhfr, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Cryptosporidium hominis
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 311009.68

構造登録者

Czyzyk, D.J.,Anderson, K.S.,Jorgensen, W.L.,Valhondo, M. (登録日: 2019-04-12, 公開日: 2019-06-19, 最終更新日: 2023-10-11)

• 主引用文献: Czyzyk, D.J.,Valhondo, M.,Jorgensen, W.L.,Anderson, K.S.; Understanding the structural basis of species selective, stereospecific inhibition for Cryptosporidium and human thymidylate synthase.; Febs Lett., 593:2069-2078, 2019; PubMed: 31172516; DOI: 10.1002/1873-3468.13474

実験手法

X-RAY DIFFRACTION (3.214 Å)