6OIN

Crystal structure of MYST acetyltransferase domain in complex with inhibitor CTX-124143

6OIN の概要

• エントリーDOI: 10.2210/pdb6oin/pdb
• 分子名称: Histone acetyltransferase KAT8, ZINC ION, 2-fluoro-N'-[(naphthalen-2-yl)sulfonyl]benzohydrazide, ... (5 entities in total)
• 機能のキーワード: inhibitor, complex, myst, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32641.92

構造登録者

Hermans, S.J.,Chung, M.C.,Parker, M.W.,Thomas, T.,Baell, J.B. (登録日: 2019-04-09, 公開日: 2019-07-03, 最終更新日: 2019-08-21)

• 主引用文献: Leaver, D.J.,Cleary, B.,Nguyen, N.,Priebbenow, D.L.,Lagiakos, H.R.,Sanchez, J.,Xue, L.,Huang, F.,Sun, Y.,Mujumdar, P.,Mudududdla, R.,Varghese, S.,Teguh, S.,Charman, S.A.,White, K.L.,Katneni, K.,Cuellar, M.,Strasser, J.M.,Dahlin, J.L.,Walters, M.A.,Street, I.P.,Monahan, B.J.,Jarman, K.E.,Sabroux, H.J.,Falk, H.,Chung, M.C.,Hermans, S.J.,Parker, M.W.,Thomas, T.,Baell, J.B.; Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A.; J.Med.Chem., 62:7146-7159, 2019; PubMed: 31256587; DOI: 10.1021/acs.jmedchem.9b00665

実験手法

X-RAY DIFFRACTION (1.7 Å)