6OGV

X-ray crystal structure of darunavir-resistant HIV-1 protease (P30) in apo state

Summary for 6OGV

• Entry DOI: 10.2210/pdb6ogv/pdb
• Descriptor: Protease (2 entities in total)
• Functional Keywords: inhibitor, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 1
• Total formula weight: 10781.58

Authors

Bulut, H.,Hattori, S.I.,Aoki-Ogata, H.,Hayashi, H.,Aoki, M.,Ghosh, A.K.,Mitsuya, H. (deposition date: 2019-04-03, release date: 2020-04-08, Last modification date: 2023-10-11)

• Primary citation: Bulut, H.,Hattori, S.I.,Aoki-Ogata, H.,Hayashi, H.,Aoki, M.,Ghosh, A.K.,Mitsuya, H.; Novel HIV-1 protease inhibitors, GRL-142 and its analogs, markedly adapt to the structural plasticity of HIV-1 protease and exerts extreme potency with high genetic barrier; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.57 Å)