6OGV
X-ray crystal structure of darunavir-resistant HIV-1 protease (P30) in apo state
Summary for 6OGV
Entry DOI | 10.2210/pdb6ogv/pdb |
Descriptor | Protease (2 entities in total) |
Functional Keywords | inhibitor, viral protein, viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 1 |
Total formula weight | 10781.58 |
Authors | Bulut, H.,Hattori, S.I.,Aoki-Ogata, H.,Hayashi, H.,Aoki, M.,Ghosh, A.K.,Mitsuya, H. (deposition date: 2019-04-03, release date: 2020-04-08, Last modification date: 2023-10-11) |
Primary citation | Bulut, H.,Hattori, S.I.,Aoki-Ogata, H.,Hayashi, H.,Aoki, M.,Ghosh, A.K.,Mitsuya, H. Novel HIV-1 protease inhibitors, GRL-142 and its analogs, markedly adapt to the structural plasticity of HIV-1 protease and exerts extreme potency with high genetic barrier To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.57 Å) |
Structure validation
Download full validation report