6OGV

X-ray crystal structure of darunavir-resistant HIV-1 protease (P30) in apo state

6OGV の概要

• エントリーDOI: 10.2210/pdb6ogv/pdb
• 分子名称: Protease (2 entities in total)
• 機能のキーワード: inhibitor, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10781.58

構造登録者

Bulut, H.,Hattori, S.I.,Aoki-Ogata, H.,Hayashi, H.,Aoki, M.,Ghosh, A.K.,Mitsuya, H. (登録日: 2019-04-03, 公開日: 2020-04-08, 最終更新日: 2023-10-11)

• 主引用文献: Bulut, H.,Hattori, S.I.,Aoki-Ogata, H.,Hayashi, H.,Aoki, M.,Ghosh, A.K.,Mitsuya, H.; Novel HIV-1 protease inhibitors, GRL-142 and its analogs, markedly adapt to the structural plasticity of HIV-1 protease and exerts extreme potency with high genetic barrier; To Be Published,

実験手法

X-RAY DIFFRACTION (1.57 Å)