6OE3

Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-7-fluoro-2-naphthonitrile (JLJ635), a Non-nucleoside Inhibitor

Summary for 6OE3

• Entry DOI: 10.2210/pdb6oe3/pdb
• Descriptor: HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT, HIV-1 REVERSE TRANSCRIPTASE, P51 SUBUNIT, 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-7-fluoronaphthalene-2-carbonitrile, ... (6 entities in total)
• Functional Keywords: nnrtis, hiv-1, drug design, transferase
• Biological source: Human immunodeficiency virus type 1 group M subtype B (isolate BH10); More
• Total number of polymer chains: 2
• Total formula weight: 114566.48

Authors

Bertoletti, N.,Kudalkar, S.N.,Anderson, K.S.,Cisneros Trigo, J.A.,Jorgensen, W.L. (deposition date: 2019-03-27, release date: 2019-05-15, Last modification date: 2023-10-11)

• Primary citation: Kudalkar, S.N.,Ullah, I.,Bertoletti, N.,Mandl, H.K.,Cisneros, J.A.,Beloor, J.,Chan, A.H.,Quijano, E.,Saltzman, W.M.,Jorgensen, W.L.,Kumar, P.,Anderson, K.S.; Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV.; Antiviral Res., 167:110-116, 2019; PubMed: 31034849; DOI: 10.1016/j.antiviral.2019.04.010

Experimental method

X-RAY DIFFRACTION (2.9 Å)