6OE3
Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-7-fluoro-2-naphthonitrile (JLJ635), a Non-nucleoside Inhibitor
6OE3 の概要
エントリーDOI | 10.2210/pdb6oe3/pdb |
分子名称 | HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT, HIV-1 REVERSE TRANSCRIPTASE, P51 SUBUNIT, 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-7-fluoronaphthalene-2-carbonitrile, ... (6 entities in total) |
機能のキーワード | nnrtis, hiv-1, drug design, transferase |
由来する生物種 | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 114566.48 |
構造登録者 | Bertoletti, N.,Kudalkar, S.N.,Anderson, K.S.,Cisneros Trigo, J.A.,Jorgensen, W.L. (登録日: 2019-03-27, 公開日: 2019-05-15, 最終更新日: 2023-10-11) |
主引用文献 | Kudalkar, S.N.,Ullah, I.,Bertoletti, N.,Mandl, H.K.,Cisneros, J.A.,Beloor, J.,Chan, A.H.,Quijano, E.,Saltzman, W.M.,Jorgensen, W.L.,Kumar, P.,Anderson, K.S. Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV. Antiviral Res., 167:110-116, 2019 Cited by PubMed: 31034849DOI: 10.1016/j.antiviral.2019.04.010 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.9 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード