6OE1

Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects

6OE1 の概要

• エントリーDOI: 10.2210/pdb6oe1/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: carbonic anhydrase inhibitors, metalloenzymes, organoselenium, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29923.05

構造登録者

Peat, T.S. (登録日: 2019-03-27, 公開日: 2019-06-12, 最終更新日: 2023-10-11)

• 主引用文献: Angeli, A.,Di Cesare Mannelli, L.,Ghelardini, C.,Peat, T.S.,Bartolucci, G.,Menicatti, M.,Carta, F.,Supuran, C.T.; Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects.; Eur.J.Med.Chem., 177:188-197, 2019; PubMed: 31136893; DOI: 10.1016/j.ejmech.2019.05.058

実験手法

X-RAY DIFFRACTION (1.45 Å)