6ODB

Crystal structure of HDAC8 in complex with compound 3

6ODB の概要

• エントリーDOI: 10.2210/pdb6odb/pdb
• 分子名称: Histone deacetylase 8, N-{2-[(1E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl]phenyl}-2-phenoxybenzamide, ZINC ION, ... (6 entities in total)
• 機能のキーワード: histone deacetylase, hdac8, hydroxamic acid, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 139850.08

構造登録者

Zheng, X.,Conti, C.,Caravella, J.,Zablocki, M.-M.,Bair, K.,Barczak, N.,Han, B.,Lancia Jr., D.,Liu, C.,Martin, M.,Ng, P.Y.,Rudnitskaya, A.,Thomason, J.J.,Garcia-Dancey, R.,Hardy, C.,Lahdenranta, J.,Leng, C.,Li, P.,Pardo, E.,Saldahna, A.,Tan, T.,Toms, A.V.,Yao, L.,Zhang, C. (登録日: 2019-03-26, 公開日: 2020-04-01, 最終更新日: 2023-10-11)

• 主引用文献: Zheng, X.,Conti, C.,Caravella, J.,Zablocki, M.-M.,Bair, K.,Barczak, N.,Han, B.,Lancia Jr., D.,Liu, C.,Martin, M.,Ng, P.Y.,Rudnitskaya, A.,Thomason, J.J.,Garcia-Dancey, R.,Hardy, C.,Lahdenranta, J.,Leng, C.,Li, P.,Pardo, E.,Saldahna, A.,Tan, T.,Toms, A.V.,Yao, L.,Zhang, C.; Structure-based Discovery of Novel N-(E)-N-Hydroxy-3-(2-(2-oxoimidazolidin-1-yl)phenyl)acrylamides as Potent and Selective HDAC8 inhibitors; To Be Published,

実験手法

X-RAY DIFFRACTION (2.7 Å)