6OBF

JAK2 JH2 in complex with JAK179

Summary for 6OBF

Entry DOI	10.2210/pdb6obf/pdb
Descriptor	Tyrosine-protein kinase JAK2, GLYCEROL, [4-({5-amino-3-[(4-sulfamoylphenyl)amino]-1H-1,2,4-triazole-1-carbonyl}amino)phenoxy]acetic acid, ... (4 entities in total)
Functional Keywords	pseudokinase domain, inhibitor, complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33660.48
Authors	Krimmer, S.G.,Liosi, M.E.,Schlessinger, J.,Jorgensen, W.L. (deposition date: 2019-03-20, release date: 2020-03-25, Last modification date: 2023-10-11)
Primary citation	Liosi, M.E.,Krimmer, S.G.,Newton, A.S.,Dawson, T.K.,Puleo, D.E.,Cutrona, K.J.,Suzuki, Y.,Schlessinger, J.,Jorgensen, W.L. Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core. J.Med.Chem., 63:5324-5340, 2020 Cited by PubMed: 32329617 DOI: 10.1021/acs.jmedchem.0c00192 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.71 Å)

Structure validation