6OBB
JAK2 JH2 in complex with JAK170
Summary for 6OBB
| Entry DOI | 10.2210/pdb6obb/pdb |
| Descriptor | Tyrosine-protein kinase JAK2, 5-amino-N-phenyl-3-[(4-sulfamoylphenyl)amino]-1H-1,2,4-triazole-1-carboxamide (3 entities in total) |
| Functional Keywords | pseudokinase domain, inhibitor, complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 33494.35 |
| Authors | Krimmer, S.G.,Liosi, M.E.,Puleo, D.E.,Schlessinger, J.,Jorgensen, W.L. (deposition date: 2019-03-20, release date: 2020-03-25, Last modification date: 2023-10-11) |
| Primary citation | Liosi, M.E.,Krimmer, S.G.,Newton, A.S.,Dawson, T.K.,Puleo, D.E.,Cutrona, K.J.,Suzuki, Y.,Schlessinger, J.,Jorgensen, W.L. Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core. J.Med.Chem., 63:5324-5340, 2020 Cited by PubMed: 32329617DOI: 10.1021/acs.jmedchem.0c00192 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.904 Å) |
Structure validation
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