6O9D

Structure of the IRAK4 kinase domain with compound 5

6O9D の概要

• エントリーDOI: 10.2210/pdb6o9d/pdb
• 分子名称: Interleukin-1 receptor-associated kinase 4, N-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide (3 entities in total)
• 機能のキーワード: kinase, irak4, irak1, irak2, irak3, immune system
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 146287.98

構造登録者

Yu, C.,Drobnick, J.,Bryan, M.C.,Kiefer, J.,Lupardus, P.J. (登録日: 2019-03-13, 公開日: 2019-05-22, 最終更新日: 2024-04-03)

• 主引用文献: Bryan, M.C.,Drobnick, J.,Gobbi, A.,Kolesnikov, A.,Chen, Y.,Rajapaksa, N.,Ndubaku, C.,Feng, J.,Chang, W.,Francis, R.,Yu, C.,Choo, E.F.,DeMent, K.,Ran, Y.,An, L.,Emson, C.,Huang, Z.,Sujatha-Bhaskar, S.,Brightbill, H.,DiPasquale, A.,Maher, J.,Wai, J.,McKenzie, B.S.,Lupardus, P.J.,Zarrin, A.A.,Kiefer, J.R.; Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors.; J.Med.Chem., 62:6223-6240, 2019; PubMed: 31082230; DOI: 10.1021/acs.jmedchem.9b00439

実験手法

X-RAY DIFFRACTION (2.51 Å)