6O94

Structure of the IRAK4 kinase domain with compound 17

Summary for 6O94

• Entry DOI: 10.2210/pdb6o94/pdb
• Descriptor: Interleukin-1 receptor-associated kinase 4, CALCIUM ION, N-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1H-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide, ... (4 entities in total)
• Functional Keywords: kinase, irak4, irak1, irak2, irak3, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 146724.51

Authors

Yu, C.,Drobnick, J.,Bryan, M.C.,Kiefer, J.,Lupardus, P.J. (deposition date: 2019-03-13, release date: 2019-05-22, Last modification date: 2024-04-03)

• Primary citation: Bryan, M.C.,Drobnick, J.,Gobbi, A.,Kolesnikov, A.,Chen, Y.,Rajapaksa, N.,Ndubaku, C.,Feng, J.,Chang, W.,Francis, R.,Yu, C.,Choo, E.F.,DeMent, K.,Ran, Y.,An, L.,Emson, C.,Huang, Z.,Sujatha-Bhaskar, S.,Brightbill, H.,DiPasquale, A.,Maher, J.,Wai, J.,McKenzie, B.S.,Lupardus, P.J.,Zarrin, A.A.,Kiefer, J.R.; Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors.; J.Med.Chem., 62:6223-6240, 2019; PubMed: 31082230; DOI: 10.1021/acs.jmedchem.9b00439

Experimental method

X-RAY DIFFRACTION (1.98 Å)