6O8R

Syn-safencin 24

6O8R の概要

• エントリーDOI: 10.2210/pdb6o8r/pdb
• NMR情報: BMRB: 30587
• 分子名称: Circular bacteriocin, circularin A/uberolysin family (1 entity in total)
• 機能のキーワード: antimicrobial, synthetic peptide, antimicrobial protein
• 由来する生物種: Bacillus safensis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3061.82

構造登録者

Fields, F.R.,Lee, S.W. (登録日: 2019-03-11, 公開日: 2020-05-13, 最終更新日: 2024-05-15)

主引用文献

Fields, F.R.,Manzo, G.,Hind, C.K.,Janardhanan, J.,Foik, I.P.,Carmo Silva, P.D.,Balsara, R.D.,Clifford, M.,Vu, H.M.,Ross, J.N.,Kalwajtys, V.R.,Gonzalez, A.J.,Bui, T.T.,Ploplis, V.A.,Castellino, F.J.,Siryaporn, A.,Chang, M.,Sutton, J.M.,Mason, A.J.,Lee, S.
Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy.
Acs Pharmacol Transl Sci, 3:418-424, 2020

PubMed Abstract: The ribosomally produced antimicrobial peptides of bacteria (bacteriocins) represent an unexplored source of membrane-active antibiotics. We designed a library of linear peptides from a circular bacteriocin and show that pore-formation dynamics in bacterial membranes are tunable via selective amino acid substitution. We observed antibacterial interpeptide synergy indicating that fundamentally altering interactions with the membrane enables synergy. Our findings suggest an approach for engineering pore-formation through rational peptide design and increasing the utility of novel antimicrobial peptides by exploiting synergy.

PubMed: 32566907
DOI: 10.1021/acsptsci.0c00001
主引用文献が同じPDBエントリー

実験手法

SOLUTION NMR