6O89
Anti-CD28xCD3 CODV Fab
Summary for 6O89
Entry DOI | 10.2210/pdb6o89/pdb |
Related | 6O8D |
Descriptor | Anti-CD28xCD3 CODV-Fab Heavy chain, Anti-CD28xCD3 CODV-Fab Light chain (3 entities in total) |
Functional Keywords | cross-over dual variable immunoglobin, multifunctional biotherapeutic format, bispecific property, codv, immune system, t cell activation |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 75987.65 |
Authors | Lord, D.M.,Wei, R.R. (deposition date: 2019-03-09, release date: 2019-11-20, Last modification date: 2023-10-11) |
Primary citation | Wu, L.,Seung, E.,Xu, L.,Rao, E.,Lord, D.M.,Wei, R.R.,Cortez-Retamozo, V.,Ospina, B.,Posternak, V.,Ulinski, G.,Piepenhagen, P.,Francesconi, E.,El Murr, N.,Beil, C.,Dabdoubi, T.,Cameron, B.,Bertrand, T.,Ferrari, P.,Pouzieux, S.,Lemoine, C.,Prades, C.,Park, A.,Qiu, H.,Song, Z.,Zhang, B.,Sun, F.,Chiron, M.,Rao, S.,Radosevic, K.,Zhi-yong, Y.,Nabel, G.J. Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation Nat Cancer, 1:86-98, 2020 Cited by DOI: 10.1038/s43018-019-0004-zPDB entries with the same primary citation |
Experimental method |
Structure validation
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