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6O61

Tubulin-RB3_SLD-TTL in complex with compound ABI-231

Summary for 6O61
Entry DOI10.2210/pdb6o61/pdb
Related6O5M 6O5N
DescriptorTubulin alpha-1B chain, [2-(1H-indol-3-yl)-1H-imidazol-5-yl](3,4,5-trimethoxyphenyl)methanone, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
Functional Keywordsmicrotubule inhibitor, colchicine, cancer, cell cycle
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains6
Total formula weight265041.28
Authors
Kumar, G.,Wang, Y.,Li, W.,White, S.W. (deposition date: 2019-03-05, release date: 2019-07-10, Last modification date: 2024-03-13)
Primary citationWang, Q.,Arnst, K.E.,Wang, Y.,Kumar, G.,Ma, D.,White, S.W.,Miller, D.D.,Li, W.,Li, W.
Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin.
J.Med.Chem., 62:6734-6750, 2019
Cited by
PubMed: 31251599
DOI: 10.1021/acs.jmedchem.9b00706
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.599 Å)
Structure validation

217705

數據於2024-03-27公開中

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