6O5X
Crystal Structure of multi-drug resistant HIV-1 protease PR-S17 with substrate analog CA-p2
Summary for 6O5X
Entry DOI | 10.2210/pdb6o5x/pdb |
Related PRD ID | PRD_000349 |
Descriptor | HIV-1 protease PR-S17, CHLORIDE ION, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, ... (5 entities in total) |
Functional Keywords | hiv protease, hydrolase, viral protein |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 4 |
Total formula weight | 45280.91 |
Authors | Agniswamy, J.,Wang, Y.-F.,Weber, I.T. (deposition date: 2019-03-04, release date: 2019-06-19, Last modification date: 2023-10-11) |
Primary citation | Agniswamy, J.,Kneller, D.W.,Brothers, R.,Wang, Y.F.,Harrison, R.W.,Weber, I.T. Highly Drug-Resistant HIV-1 Protease Mutant PRS17 Shows Enhanced Binding to Substrate Analogues. Acs Omega, 4:8707-8719, 2019 Cited by PubMed: 31172041DOI: 10.1021/acsomega.9b00683 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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