Crystal Structure of multi-drug resistant HIV-1 protease PR-S17 with substrate analog CA-p2

Summary for 6O5X

Related PRD IDPRD_000349
DescriptorHIV-1 protease PR-S17, CHLORIDE ION, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, ... (5 entities in total)
Functional Keywordshiv protease, hydrolase, viral protein
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains4
Total molecular weight45280.91
Agniswamy, J.,Wang, Y.-F.,Weber, I.T. (deposition date: 2019-03-04, release date: 2019-06-19, Last modification date: 2019-07-17)
Primary citation
Agniswamy, J.,Kneller, D.W.,Brothers, R.,Wang, Y.F.,Harrison, R.W.,Weber, I.T.
Highly Drug-Resistant HIV-1 Protease Mutant PRS17 Shows Enhanced Binding to Substrate Analogues.
Acs Omega, 4:8707-8719, 2019
PubMed: 31172041 (PDB entries with the same primary citation)
DOI: 10.1021/acsomega.9b00683
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21560 0.9% 1.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution