6O5X

Crystal Structure of multi-drug resistant HIV-1 protease PR-S17 with substrate analog CA-p2

6O5X の概要

関連するBIRD辞書のPRD_IDPRD_000349
分子名称HIV-1 protease PR-S17, CHLORIDE ION, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, ... (5 entities in total)
機能のキーワードhiv protease, hydrolase, viral protein
由来する生物種Human immunodeficiency virus 1
ポリマー鎖数4
分子量合計45280.91
構造登録者
Agniswamy, J.,Wang, Y.-F.,Weber, I.T. (登録日: 2019-03-04, 公開日: 2019-06-19, 最終更新日: 2019-07-17)
主引用文献
Agniswamy, J.,Kneller, D.W.,Brothers, R.,Wang, Y.F.,Harrison, R.W.,Weber, I.T.
Highly Drug-Resistant HIV-1 Protease Mutant PRS17 Shows Enhanced Binding to Substrate Analogues.
Acs Omega, 4:8707-8719, 2019
PubMed: 31172041 (主引用文献が同じPDBエントリー)
DOI: 10.1021/acsomega.9b00683
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.7 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21560 0.9% 1.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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