6O5S

Room temperature structure of VX-phosphonylated hAChE in complex with oxime reactivator RS-170B

6O5S の概要

• エントリーDOI: 10.2210/pdb6o5s/pdb
• 関連するPDBエントリー: 6o5r
• 分子名称: Acetylcholinesterase, O-ETHYLMETHYLPHOSPHONIC ACID ESTER GROUP, 4-carbamoyl-1-(3-{2-[(E)-(hydroxyimino)methyl]-1H-imidazol-1-yl}propyl)pyridin-1-ium, ... (4 entities in total)
• 機能のキーワード: vx-phosphonylated, vx-hache, oxime reactivator, imidazole-based oxime, rs-170b, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 121620.85

構造登録者

Gerlits, O.,Kovalevsky, A.,Radic, Z. (登録日: 2019-03-04, 公開日: 2019-05-29, 最終更新日: 2023-10-11)

• 主引用文献: Gerlits, O.,Kong, X.,Cheng, X.,Wymore, T.,Blumenthal, D.K.,Taylor, P.,Radic, Z.,Kovalevsky, A.; Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase.; J.Biol.Chem., 294:10607-10618, 2019; PubMed: 31138650; DOI: 10.1074/jbc.RA119.008725

実験手法

X-RAY DIFFRACTION (2.801 Å)