6O5M
Tubulin-RB3_SLD-TTL in complex with compound 10bb
Summary for 6O5M
Entry DOI | 10.2210/pdb6o5m/pdb |
Descriptor | Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, [2-(1H-indol-4-yl)-1H-imidazol-4-yl](3,4,5-trimethoxyphenyl)methanone, ... (13 entities in total) |
Functional Keywords | microtubule inhibitor, colchicine, cancer, cell cycle |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 265329.75 |
Authors | Kumar, G.,Wang, Y.,Li, W.,White, S.W. (deposition date: 2019-03-04, release date: 2019-07-10, Last modification date: 2024-03-13) |
Primary citation | Wang, Q.,Arnst, K.E.,Wang, Y.,Kumar, G.,Ma, D.,White, S.W.,Miller, D.D.,Li, W.,Li, W. Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin. J.Med.Chem., 62:6734-6750, 2019 Cited by PubMed: 31251599DOI: 10.1021/acs.jmedchem.9b00706 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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