6O5M

Tubulin-RB3_SLD-TTL in complex with compound 10bb

6O5M の概要

• エントリーDOI: 10.2210/pdb6o5m/pdb
• 分子名称: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, [2-(1H-indol-4-yl)-1H-imidazol-4-yl](3,4,5-trimethoxyphenyl)methanone, ... (13 entities in total)
• 機能のキーワード: microtubule inhibitor, colchicine, cancer, cell cycle
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 265329.75

構造登録者

Kumar, G.,Wang, Y.,Li, W.,White, S.W. (登録日: 2019-03-04, 公開日: 2019-07-10, 最終更新日: 2024-03-13)

• 主引用文献: Wang, Q.,Arnst, K.E.,Wang, Y.,Kumar, G.,Ma, D.,White, S.W.,Miller, D.D.,Li, W.,Li, W.; Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin.; J.Med.Chem., 62:6734-6750, 2019; PubMed: 31251599; DOI: 10.1021/acs.jmedchem.9b00706

実験手法

X-RAY DIFFRACTION (2.3 Å)