Wild-type HIV-1 protease in complex with a substrate analog CA-p2

Summary for 6O48

Related1A8K 6O5X
Related PRD IDPRD_000349
DescriptorHIV-1 protease, SODIUM ION, CHLORIDE ION, ... (7 entities in total)
Functional Keywordshiv protease, hydrolase, viral protein
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total molecular weight22546.42
Wang, Y.-F.,Liu, F.,Weber, I.T. (deposition date: 2019-02-28, release date: 2019-06-19, Last modification date: 2019-07-17)
Primary citation
Agniswamy, J.,Kneller, D.W.,Brothers, R.,Wang, Y.F.,Harrison, R.W.,Weber, I.T.
Highly Drug-Resistant HIV-1 Protease Mutant PRS17 Shows Enhanced Binding to Substrate Analogues.
Acs Omega, 4:8707-8719, 2019
PubMed: 31172041 (PDB entries with the same primary citation)
DOI: 10.1021/acsomega.9b00683
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.214900 1.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution