6O0K

crystal structure of BCL-2 with venetoclax

Summary for 6O0K

• Entry DOI: 10.2210/pdb6o0k/pdb
• Descriptor: Apoptosis regulator Bcl-2, 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide, NONAETHYLENE GLYCOL, ... (4 entities in total)
• Functional Keywords: bcl-2, venetoclax, complex, protein-protein interface inhibitor, fda approved drug complex, apoptosis
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 20640.48

Authors

Birkinshaw, R.W.,Luo, C.S.,Colman, P.M.,Czabotar, P.E. (deposition date: 2019-02-16, release date: 2019-05-22, Last modification date: 2023-10-11)

• Primary citation: Birkinshaw, R.W.,Gong, J.N.,Luo, C.S.,Lio, D.,White, C.A.,Anderson, M.A.,Blombery, P.,Lessene, G.,Majewski, I.J.,Thijssen, R.,Roberts, A.W.,Huang, D.C.S.,Colman, P.M.,Czabotar, P.E.; Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.; Nat Commun, 10:2385-2385, 2019; PubMed: 31160589; DOI: 10.1038/s41467-019-10363-1

Experimental method

X-RAY DIFFRACTION (1.62 Å)