6NTU
Crystal Structure of human PARP-1 ART domain bound to inhibitor UKTT-15
Summary for 6NTU
Entry DOI | 10.2210/pdb6ntu/pdb |
Related | 5DS3 |
Related PRD ID | PRD_900003 |
Descriptor | Poly [ADP-ribose] polymerase 1, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, DIMETHYL SULFOXIDE, ... (7 entities in total) |
Functional Keywords | parp-1, poly(adp-ribose) polymerase, parp inhibitor, parp1, artd1, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 31417.74 |
Authors | Langelier, M.F.,Pascal, J.M. (deposition date: 2019-01-30, release date: 2020-02-05, Last modification date: 2023-10-11) |
Primary citation | Zandarashvili, L.,Langelier, M.F.,Velagapudi, U.K.,Hancock, M.A.,Steffen, J.D.,Billur, R.,Hannan, Z.M.,Wicks, A.J.,Krastev, D.B.,Pettitt, S.J.,Lord, C.J.,Talele, T.T.,Pascal, J.M.,Black, B.E. Structural basis for allosteric PARP-1 retention on DNA breaks. Science, 368:-, 2020 Cited by PubMed: 32241924DOI: 10.1126/science.aax6367 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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