6NTU

Crystal Structure of human PARP-1 ART domain bound to inhibitor UKTT-15

Summary for 6NTU

• Entry DOI: 10.2210/pdb6ntu/pdb
• Related: 5DS3
• Related PRD ID: PRD_900003
• Descriptor: Poly [ADP-ribose] polymerase 1, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, DIMETHYL SULFOXIDE, ... (7 entities in total)
• Functional Keywords: parp-1, poly(adp-ribose) polymerase, parp inhibitor, parp1, artd1, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 31417.74

Authors

Langelier, M.F.,Pascal, J.M. (deposition date: 2019-01-30, release date: 2020-02-05, Last modification date: 2023-10-11)

• Primary citation: Zandarashvili, L.,Langelier, M.F.,Velagapudi, U.K.,Hancock, M.A.,Steffen, J.D.,Billur, R.,Hannan, Z.M.,Wicks, A.J.,Krastev, D.B.,Pettitt, S.J.,Lord, C.J.,Talele, T.T.,Pascal, J.M.,Black, B.E.; Structural basis for allosteric PARP-1 retention on DNA breaks.; Science, 368:-, 2020; PubMed: 32241924; DOI: 10.1126/science.aax6367

Experimental method

X-RAY DIFFRACTION (1.8 Å)