6NSV

Crystal structure of the human CHIP TPR domain in complex with a 5mer acetylated optimized peptide

Summary for 6NSV

Entry DOI	10.2210/pdb6nsv/pdb
Descriptor	E3 ubiquitin-protein ligase CHIP, ACE-LEU-TRP-TRP-PRO-ASP, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	chip, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	31857.50
Authors	Basu, K.,Ravalin, M.,Bohn, M.-F.,Craik, C.S.,Gestwicki, J.E. (deposition date: 2019-01-25, release date: 2019-07-31, Last modification date: 2023-10-11)
Primary citation	Ravalin, M.,Theofilas, P.,Basu, K.,Opoku-Nsiah, K.A.,Assimon, V.A.,Medina-Cleghorn, D.,Chen, Y.F.,Bohn, M.F.,Arkin, M.,Grinberg, L.T.,Craik, C.S.,Gestwicki, J.E. Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases. Nat.Chem.Biol., 15:786-794, 2019 Cited by PubMed: 31320752 DOI: 10.1038/s41589-019-0322-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.305 Å)

Structure validation