6NSQ
Crystal structure of BRAF kinase domain bound to the inhibitor 2l
Summary for 6NSQ
| Entry DOI | 10.2210/pdb6nsq/pdb |
| Descriptor | Serine/threonine-protein kinase B-raf, 5-[(4-amino-1-ethyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine (3 entities in total) |
| Functional Keywords | braf inhibitors, signaling protein, transferase-transferase inhibitor complex, transferase, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 65407.73 |
| Authors | Maisonneuve, P.,Kurinov, I.,Assadieskandar, A.,Yu, C.,Zhang, C.,Sicheri, F. (deposition date: 2019-01-25, release date: 2019-06-19, Last modification date: 2023-10-11) |
| Primary citation | Assadieskandar, A.,Yu, C.,Maisonneuve, P.,Kurinov, I.,Sicheri, F.,Zhang, C. Rigidification Dramatically Improves Inhibitor Selectivity for RAF Kinases. Acs Med.Chem.Lett., 10:1074-1080, 2019 Cited by PubMed: 31312411DOI: 10.1021/acsmedchemlett.9b00194 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.05 Å) |
Structure validation
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