6NSQ

Crystal structure of BRAF kinase domain bound to the inhibitor 2l

6NSQ の概要

• エントリーDOI: 10.2210/pdb6nsq/pdb
• 分子名称: Serine/threonine-protein kinase B-raf, 5-[(4-amino-1-ethyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine (3 entities in total)
• 機能のキーワード: braf inhibitors, signaling protein, transferase-transferase inhibitor complex, transferase, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65407.73

構造登録者

Maisonneuve, P.,Kurinov, I.,Assadieskandar, A.,Yu, C.,Zhang, C.,Sicheri, F. (登録日: 2019-01-25, 公開日: 2019-06-19, 最終更新日: 2023-10-11)

• 主引用文献: Assadieskandar, A.,Yu, C.,Maisonneuve, P.,Kurinov, I.,Sicheri, F.,Zhang, C.; Rigidification Dramatically Improves Inhibitor Selectivity for RAF Kinases.; Acs Med.Chem.Lett., 10:1074-1080, 2019; PubMed: 31312411; DOI: 10.1021/acsmedchemlett.9b00194

実験手法

X-RAY DIFFRACTION (3.05 Å)