6NSL

CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound-6c AKA 6-((1-(4-CYANOPHENY L)-2-OXO-1,2-DIHYDRO-3-PYRIDINYL)AMINO)-N-CYCLOPROPYL-8-(M ETHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBOXAMIDE

6NSL の概要

• エントリーDOI: 10.2210/pdb6nsl/pdb
• 分子名称: Non-receptor tyrosine-protein kinase TYK2, 6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}-N-cyclopropyl-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72167.42

構造登録者

Muckelbauer, J.M.,Khan, J.A. (登録日: 2019-01-25, 公開日: 2020-01-29, 最終更新日: 2024-03-13)

• 主引用文献: Liu, C.,Lin, J.,Moslin, R.,Tokarski, J.S.,Muckelbauer, J.,Chang, C.,Tredup, J.,Xie, D.,Park, H.,Li, P.,Wu, D.R.,Strnad, J.,Zupa-Fernandez, A.,Cheng, L.,Chaudhry, C.,Chen, J.,Chen, C.,Sun, H.,Elzinga, P.,D'arienzo, C.,Gillooly, K.,Taylor, T.L.,McIntyre, K.W.,Salter-Cid, L.,Lombardo, L.J.,Carter, P.H.,Aranibar, N.,Burke, J.R.,Weinstein, D.S.; Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors.; Acs Med.Chem.Lett., 10:383-388, 2019; PubMed: 30891145; DOI: 10.1021/acsmedchemlett.9b00035

実験手法

X-RAY DIFFRACTION (2.15 Å)