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6NRF

Crystal Structure of human PARP-1 ART domain bound to inhibitor UTT103

Summary for 6NRF
Entry DOI10.2210/pdb6nrf/pdb
DescriptorPoly [ADP-ribose] polymerase 1, CITRIC ACID, DIMETHYL SULFOXIDE, ... (6 entities in total)
Functional Keywordsparp-1, poly(adp-ribose) polymerase, parp inhibitor, parp1, artd1, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight30839.97
Authors
Langelier, M.F.,Pascal, J.M. (deposition date: 2019-01-23, release date: 2019-08-14, Last modification date: 2023-10-11)
Primary citationVelagapudi, U.K.,Langelier, M.F.,Delgado-Martin, C.,Diolaiti, M.E.,Bakker, S.,Ashworth, A.,Patel, B.A.,Shao, X.,Pascal, J.M.,Talele, T.T.
Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity.
J.Med.Chem., 62:5330-5357, 2019
Cited by
PubMed: 31042381
DOI: 10.1021/acs.jmedchem.8b01709
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

217705

건을2024-03-27부터공개중

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