6NR4

Cryo-EM structure of the TRPM8 ion channel with low occupancy icilin, PI(4,5)P2, and calcium

6NR4 の概要

• エントリーDOI: 10.2210/pdb6nr4/pdb
• EMDBエントリー: 0487 0488 0489
• 分子名称: Transient receptor potential cation channel subfamily M member 8 (1 entity in total)
• 機能のキーワード: ion channel, trp channel, trpm channel, trpm8 channel, cold sensing, lipid sensing, menthol, icilin, ws-12, pi(4, 5)p2, calcium-permeable channel, cooling agent, transport protein
• 由来する生物種: Ficedula albicollis (Collared flycatcher); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 518771.75

構造登録者

Yin, Y.,Le, S.C.,Hsu, A.L.,Borgnia, M.J.,Yang, H.,Lee, S.-Y. (登録日: 2019-01-22, 公開日: 2019-02-20, 最終更新日: 2019-12-18)

• 主引用文献: Yin, Y.,Le, S.C.,Hsu, A.L.,Borgnia, M.J.,Yang, H.,Lee, S.Y.; Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.; Science, 363:-, 2019; PubMed: 30733385; DOI: 10.1126/science.aav9334

実験手法

ELECTRON MICROSCOPY (4.3 Å)