6NNW

Tsn15 in complex with substrate intermediate

Summary for 6NNW

• Entry DOI: 10.2210/pdb6nnw/pdb
• Descriptor: Tetronasin, (3E)-3-{(1S,4S,4aS,5R,8aS)-1-[(2E,4R,7S,8E,10S)-1,7-dihydroxy-10-{(2R,3S,5R)-5-[(1S)-1-methoxyethyl]-3-methyloxolan-2-yl}-4-methylundeca-2,8-dien-2-yl]-4,5-dimethyloctahydro-3H-2-benzopyran-3-ylidene}oxolane-2,4-dione, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: complex, cyclase, unknown function
• Biological source: Streptomyces longisporoflavus
• Total number of polymer chains: 2
• Total formula weight: 46761.45

Authors

Paiva, F.C.R.,Little, R.,Leadlay, P.,Dias, M.V.B. (deposition date: 2019-01-15, release date: 2019-10-23, Last modification date: 2023-10-11)

• Primary citation: Little, R.,Paiva, F.C.R.,Jenkins, R.,Hong, H.,Sun, Y.,Demydchuk, Y.,Samborskyy, M.,Tosin, M.,Leeper, F.J.,Dias, M.V.B.,Leadlay, P.F.; Unexpected enzyme-catalysed [4+2] cycloaddition and rearrangement in polyether antibiotic biosynthesis; Nat Catal, 2019; DOI: 10.1038/s41929-019-0351-2

Experimental method

X-RAY DIFFRACTION (1.7 Å)