6NND

Structure of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with NADPH and dihydrofolate

6NND の概要

• エントリーDOI: 10.2210/pdb6nnd/pdb
• 関連するPDBエントリー: 6nnc
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, COBALT (II) ION, ... (6 entities in total)
• 機能のキーワード: antifolate, biosynthetic protein
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38452.83

構造登録者

Ribeiro, J.A.,Chavez-Pacheco, S.M.,Dias, M.V.B. (登録日: 2019-01-14, 公開日: 2019-07-17, 最終更新日: 2024-03-13)

• 主引用文献: Ribeiro, J.A.,Chavez-Pacheco, S.M.,de Oliveira, G.S.,Silva, C.D.S.,Giudice, J.H.P.,Libreros-Zuniga, G.A.,Dias, M.V.B.; Crystal structures of the closed form of Mycobacterium tuberculosis dihydrofolate reductase in complex with dihydrofolate and antifolates.; Acta Crystallogr D Struct Biol, 75:682-693, 2019; PubMed: 31282477; DOI: 10.1107/S205979831900901X

実験手法

X-RAY DIFFRACTION (1.7 Å)