6NLM

1.90 A resolution structure of WT BfrB from Pseudomonas aeruginosa in complex with a protein-protein interaction inhibitor (analog 15)

6NLM の概要

• エントリーDOI: 10.2210/pdb6nlm/pdb
• 分子名称: Ferroxidase, FE (II) ION, 4-{[3-(4-hydroxy-2-methoxyphenyl)propyl]amino}-1H-isoindole-1,3(2H)-dione, ... (6 entities in total)
• 機能のキーワード: electron transport, iron storage, iron binding, iron mobilization, protein-protein interaction inhibitor, oxidoreductase
• 由来する生物種: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 234662.97

構造登録者

Lovell, S.,Punchi-Hewage, A.,Battaile, K.P.,Yao, H.,Nammalwar, B.,Gnanasekaran, K.K.,Bunce, R.A.,Reitz, A.B.,Rivera, M. (登録日: 2019-01-08, 公開日: 2019-05-08, 最終更新日: 2023-10-11)

• 主引用文献: Punchi Hewage, A.N.D.,Yao, H.,Nammalwar, B.,Gnanasekaran, K.K.,Lovell, S.,Bunce, R.A.,Eshelman, K.,Phaniraj, S.M.,Lee, M.M.,Peterson, B.R.,Battaile, K.P.,Reitz, A.B.,Rivera, M.; Small Molecule Inhibitors of the BfrB-Bfd Interaction Decrease Pseudomonas aeruginosa Fitness and Potentiate Fluoroquinolone Activity.; J.Am.Chem.Soc., 141:8171-8184, 2019; PubMed: 31038945; DOI: 10.1021/jacs.9b00394

実験手法

X-RAY DIFFRACTION (1.9 Å)