6NLK
1.85 A resolution structure of WT BfrB from Pseudomonas aeruginosa in complex with a protein-protein interaction inhibitor (analog 13)
Summary for 6NLK
Entry DOI | 10.2210/pdb6nlk/pdb |
Descriptor | Ferroxidase, FE (II) ION, 4-{[3-(4-hydroxyphenyl)propyl]amino}-1H-isoindole-1,3(2H)-dione, ... (6 entities in total) |
Functional Keywords | electron transport, iron storage, iron binding, iron mobilization, protein-protein interaction inhibitor, oxidoreductase |
Biological source | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) |
Total number of polymer chains | 12 |
Total formula weight | 234302.65 |
Authors | Lovell, S.,Punchi-Hewage, A.,Battaile, K.P.,Yao, H.,Nammalwar, B.,Gnanasekaran, K.K.,Bunce, R.A.,Reitz, A.B.,Rivera, M. (deposition date: 2019-01-08, release date: 2019-05-08, Last modification date: 2023-10-11) |
Primary citation | Punchi Hewage, A.N.D.,Yao, H.,Nammalwar, B.,Gnanasekaran, K.K.,Lovell, S.,Bunce, R.A.,Eshelman, K.,Phaniraj, S.M.,Lee, M.M.,Peterson, B.R.,Battaile, K.P.,Reitz, A.B.,Rivera, M. Small Molecule Inhibitors of the BfrB-Bfd Interaction Decrease Pseudomonas aeruginosa Fitness and Potentiate Fluoroquinolone Activity. J.Am.Chem.Soc., 141:8171-8184, 2019 Cited by PubMed: 31038945DOI: 10.1021/jacs.9b00394 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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