6NLG

1.50 A resolution structure of BfrB (C89S/K96C) from Pseudomonas aeruginosa in complex with a small molecule fragment (analog 1)

6NLG の概要

• エントリーDOI: 10.2210/pdb6nlg/pdb
• 分子名称: Bacterioferritin, 5-hydroxy-1H-isoindole-1,3(2H)-dione, PROTOPORPHYRIN IX CONTAINING FE, ... (7 entities in total)
• 機能のキーワード: electron transport, iron storage, iron binding, iron mobilization, protein-protein interaction inhibitor, oxidoreductase
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 78059.60

構造登録者

Lovell, S.,Punchi-Hewage, A.,Battaile, K.P.,Yao, H.,Nammalwar, B.,Gnanasekaran, K.K.,Bunce, R.A.,Reitz, A.B.,Rivera, M. (登録日: 2019-01-08, 公開日: 2019-05-08, 最終更新日: 2023-10-11)

• 主引用文献: Punchi Hewage, A.N.D.,Yao, H.,Nammalwar, B.,Gnanasekaran, K.K.,Lovell, S.,Bunce, R.A.,Eshelman, K.,Phaniraj, S.M.,Lee, M.M.,Peterson, B.R.,Battaile, K.P.,Reitz, A.B.,Rivera, M.; Small Molecule Inhibitors of the BfrB-Bfd Interaction Decrease Pseudomonas aeruginosa Fitness and Potentiate Fluoroquinolone Activity.; J.Am.Chem.Soc., 141:8171-8184, 2019; PubMed: 31038945; DOI: 10.1021/jacs.9b00394

実験手法

X-RAY DIFFRACTION (1.5 Å)