6NKV
Ternary complex crystal structure of DNA polymerase Beta with "hot-spot sequence" with beta-gamma CHF analogue of dGTP
Summary for 6NKV
Entry DOI | 10.2210/pdb6nkv/pdb |
Descriptor | DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*TP*(2DT))-3'), DNA (5'-D(P*TP*TP*CP*GP*G)-3'), ... (9 entities in total) |
Functional Keywords | dna polymerase beta, conformational change, enzyme mechanism, transcription, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 48396.02 |
Authors | Batra, V.K.,Wilson, S.H. (deposition date: 2019-01-07, release date: 2020-01-08, Last modification date: 2024-03-13) |
Primary citation | Batra, V.K.,Alnajjar, K.S.,Sweasy, J.B.,McKenna, C.E.,Goodman, M.F.,Wilson, S.H. Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography. Biochemistry, 59:955-963, 2020 Cited by PubMed: 31999437DOI: 10.1021/acs.biochem.9b01072 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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