6NKK

Structure of PhqE Reductase/Diels-Alderase from Penicillium fellutanum in complex with NADP+ and premalbrancheamide

Summary for 6NKK

• Entry DOI: 10.2210/pdb6nkk/pdb
• Related: 6NKH
• Descriptor: Short chain dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (5aS,12aS,13aS)-12,12-dimethyl-2,3,11,12,12a,13-hexahydro-1H,5H,6H-5a,13a-(epiminomethano)indolizino[7,6-b]carbazol-14-one, ... (4 entities in total)
• Functional Keywords: reductase, diels-alderase, oxidoreductase
• Biological source: Penicillium fellutanum
• Total number of polymer chains: 6
• Total formula weight: 171800.77

Authors

Newmister, S.A.,Dan, Q.,Smith, J.L.,Sherman, D.H. (deposition date: 2019-01-07, release date: 2019-10-09, Last modification date: 2024-03-13)

• Primary citation: Dan, Q.,Newmister, S.A.,Klas, K.R.,Fraley, A.E.,McAfoos, T.J.,Somoza, A.D.,Sunderhaus, J.D.,Ye, Y.,Shende, V.V.,Yu, F.,Sanders, J.N.,Brown, W.C.,Zhao, L.,Paton, R.S.,Houk, K.N.,Smith, J.L.,Sherman, D.H.,Williams, R.M.; Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase.; Nat.Chem., 11:972-980, 2019; PubMed: 31548667; DOI: 10.1038/s41557-019-0326-6

Experimental method

X-RAY DIFFRACTION (2.299 Å)