6NJA

Structure of WT RET protein tyrosine kinase domain at 1.92A resolution.

Summary for 6NJA

Entry DOI	10.2210/pdb6nja/pdb
Descriptor	Proto-oncogene tyrosine-protein kinase receptor Ret, ADENINE, FORMIC ACID, ... (4 entities in total)
Functional Keywords	transferase, oncogene, ret, tyrosine kinase, atp-binding, thyroid cancer, non-small cell lung cancer
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	36095.37
Authors	Terzyan, S.S.,Shen, T.,Wu, J.,Mooers, B.H.M. (deposition date: 2019-01-02, release date: 2019-06-05, Last modification date: 2023-11-15)
Primary citation	Terzyan, S.S.,Shen, T.,Liu, X.,Huang, Q.,Teng, P.,Zhou, M.,Hilberg, F.,Cai, J.,Mooers, B.H.M.,Wu, J. Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib. J.Biol.Chem., 294:10428-10437, 2019 Cited by PubMed: 31118272 DOI: 10.1074/jbc.RA119.007682 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.92 Å)

Structure validation