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6NH4

Structure of human endothelial nitric oxide synthase heme domain in complex with 6-(3-fluoro-5-(2-((2R,4S)-4-fluoropyrrolidin-2-yl)ethyl)phenethyl)-4-methylpyridin-2-amine

6NH4 の概要
エントリーDOI10.2210/pdb6nh4/pdb
分子名称Endothelial nitric oxide synthase splice variant eNOS13A, PROTOPORPHYRIN IX CONTAINING FE, 6-[2-(3-fluoro-5-{2-[(2R,4S)-4-fluoropyrrolidin-2-yl]ethyl}phenyl)ethyl]-4-methylpyridin-2-amine, ... (10 entities in total)
機能のキーワードnitric oxide synthase inhibitor complex heme enzyme, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
由来する生物種Homo sapiens (Human)
タンパク質・核酸の鎖数4
化学式量合計205531.83
構造登録者
Chreifi, G.,Li, H.,Poulos, T.L. (登録日: 2018-12-21, 公開日: 2019-03-13, 最終更新日: 2023-10-11)
主引用文献Do, H.T.,Li, H.,Chreifi, G.,Poulos, T.L.,Silverman, R.B.
Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold.
J. Med. Chem., 62:2690-2707, 2019
Cited by
PubMed: 30802056
DOI: 10.1021/acs.jmedchem.8b02032
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.27 Å)
構造検証レポート
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217705

件を2024-03-27に公開中

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