6NGU

Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(3-(3-(dimethylamino)propyl)-2,5-difluorophenethyl)-4-methylpyridin-2-amine

6NGU の概要

• エントリーDOI: 10.2210/pdb6ngu/pdb
• 分子名称: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: nitric oxide synthase inhibitor complex heme enzyme, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Rattus norvegicus (Rat)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100190.86

構造登録者

Li, H.,Poulos, T.L. (登録日: 2018-12-21, 公開日: 2019-03-13, 最終更新日: 2023-10-11)

• 主引用文献: Do, H.T.,Li, H.,Chreifi, G.,Poulos, T.L.,Silverman, R.B.; Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold.; J. Med. Chem., 62:2690-2707, 2019; PubMed: 30802056; DOI: 10.1021/acs.jmedchem.8b02032

実験手法

X-RAY DIFFRACTION (2 Å)