6NGJ
Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(3-fluoro-5-(3-(methylamino)prop-1-yn-1-yl)phenethyl)-4-methylpyridin-2-amine
6NGJ の概要
エントリーDOI | 10.2210/pdb6ngj/pdb |
分子名称 | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
機能のキーワード | nitric oxide synthase inhibitor complex heme enzyme, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Rattus norvegicus (Rat) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 100118.76 |
構造登録者 | |
主引用文献 | Do, H.T.,Li, H.,Chreifi, G.,Poulos, T.L.,Silverman, R.B. Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. J. Med. Chem., 62:2690-2707, 2019 Cited by PubMed: 30802056DOI: 10.1021/acs.jmedchem.8b02032 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.756 Å) |
構造検証レポート
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