6NGC

Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(3-(3-(dimethylamino)propyl)-2,5,6-trifluorophenethyl)-4-methylpyridin-2-amine

6NGC の概要

• エントリーDOI: 10.2210/pdb6ngc/pdb
• 分子名称: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total)
• 機能のキーワード: nitric oxide synthase, inhibitor complex, heme enzyme, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100052.69

構造登録者

Li, H.,Poulos, T.L. (登録日: 2018-12-21, 公開日: 2019-03-13, 最終更新日: 2023-10-11)

• 主引用文献: Do, H.T.,Li, H.,Chreifi, G.,Poulos, T.L.,Silverman, R.B.; Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold.; J. Med. Chem., 62:2690-2707, 2019; PubMed: 30802056; DOI: 10.1021/acs.jmedchem.8b02032

実験手法

X-RAY DIFFRACTION (1.998 Å)