6NEL

4-(2-(4-fluorophenyl)-5-hydroxy-6-oxo-1,6-dihydropyridin-3-yl)benzoic acid bound to influenza 2009 pH1N1 endonuclease

6NEL の概要

• エントリーDOI: 10.2210/pdb6nel/pdb
• 分子名称: Polymerase acidic protein, MANGANESE (II) ION, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: influenza endonuclease inhibitor chelator, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: Influenza A virus (A/Luxembourg/43/2009(H1N1))
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29060.81

構造登録者

Bauman, J.D.,Arnold, E. (登録日: 2018-12-17, 公開日: 2019-05-01, 最終更新日: 2023-10-11)

• 主引用文献: Sagong, H.Y.,Bauman, J.D.,Nogales, A.,Martinez-Sobrido, L.,Arnold, E.,LaVoie, E.J.; Aryl and Arylalkyl Substituted 3-Hydroxypyridin-2(1H)-ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease.; Chemmedchem, 14:1204-1223, 2019; PubMed: 30983160; DOI: 10.1002/cmdc.201900084

実験手法

X-RAY DIFFRACTION (2 Å)